X-ray diffraction
2.01Å resolution

Human S-adenosylhomocysteine hydrolase complexed with neplanocin

Source organism: Homo sapiens
Entry authors: Yang X, Hu Y, Yin DH, Turner MA, Wang M, Borchardt RT, Howell PL, Kuczera K, Schowen RL

Function and Biology Details

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Entry contents:
1 distinct polypeptide molecule
Adenosylhomocysteinase Chain: A
Molecule details ›
Chain: A
Length: 432 amino acids
Theoretical weight: 47.77 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
  • Canonical: P23526 (Residues: 1-432; Coverage: 100%)
Gene names: AHCY, SAHH
Sequence domains:
Structure domains:

Ligands and Environments

Cofactor: Ligand NAD 1 x NAD
2 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X8C
Spacegroup: F222
Unit cell:
a: 92.83Å b: 135.67Å c: 171.49Å
α: 90° β: 90° γ: 90°
R R work R free
0.197 0.197 0.236
Expression system: Escherichia coli