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HUMAN ALPHA-THROMBIN COMPLEXED WITH AC-(D)PHE-PRO-BORO-N-BUTYL-AMIDINO-GLYCINE-OH

X-ray diffraction
2.25Å resolution
PDB entry 1lhe coloured by chain, front view.
PDB entry 1lhe coloured by chain, side view.
PDB entry 1lhe coloured by chain, top view.
Source organisms:
Assembly composition:
hetero trimer (preferred)
Entry contents: 3 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: alpha-thrombin complex and peptide
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Multimeric state: hetero trimer
Accessible surface area: 12204.54 Å2
Buried surface area: 4043.55 Å2
Dissociation area: 451.81 Å2
Dissociation energy (ΔGdiss): -0.67 kcal/mol
Dissociation entropy (TΔSdiss): 6.48 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-133105

Macromolecules

Thrombin light chain
Chain: L
Length: 36 amino acids
Theoretical weight: 4.1 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P00734 (Residues: 328-363; Coverage: 6%)
Gene name: F2
Pfam: Thrombin light chain
InterPro:
SCOP: Eukaryotic proteases
Thrombin light chain in PDB entry 1lhe, assembly 1, front view.
Thrombin light chain in PDB entry 1lhe, assembly 1, side view.
Thrombin light chain in PDB entry 1lhe, assembly 1, top view.
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Thrombin heavy chain
Chain: H
Length: 259 amino acids
Theoretical weight: 29.78 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P00734 (Residues: 364-622; Coverage: 43%)
Gene name: F2
Pfam: Trypsin
InterPro:
CATH: Trypsin-like serine proteases
SCOP: Eukaryotic proteases
Thrombin heavy chain in PDB entry 1lhe, assembly 1, front view.
Thrombin heavy chain in PDB entry 1lhe, assembly 1, side view.
Thrombin heavy chain in PDB entry 1lhe, assembly 1, top view.
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HIRUDIN
Chain: I
Length: 12 amino acids
Theoretical weight: 1.47 KDa
Source organism: Hirudo medicinalis
Expression system: Not provided
HIRUDIN in PDB entry 1lhe, assembly 1, front view.
HIRUDIN in PDB entry 1lhe, assembly 1, side view.
HIRUDIN in PDB entry 1lhe, assembly 1, top view.
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