Protein Data Bank in Europe

L-arginine + 2-oxoglutarate + O(2) = (3S)-3-hydroxy-L-arginine + succinate + CO(2)

Autocatalytic release of the core protein from the N-terminus of the togavirus structural polyprotein by hydrolysis of a -Trp-|-Ser- bond.

Acyl-[acyl-carrier-protein] + malonyl-[acyl-carrier-protein] = 3-oxoacyl-[acyl-carrier-protein] + CO(2) + [acyl-carrier-protein]

dUTP + H(2)O = dUMP + diphosphate

Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates.

RX + glutathione = HX + R-S-glutathione

L-glutamate + H(2)O + NADP(+) = 2-oxoglutarate + NH(3) + NADPH

ATP + protein L-histidine = ADP + protein N-phospho-L-histidine

Selective hydrolysis of -Xaa-Xaa-|-Yaa- bonds in which each of the Xaa can be either Arg or Lys and Yaa can be either Ser or Ala.

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate

Catechol + O(2) = cis,cis-muconate

Hydrolysis of four peptide bonds in the viral precursor polyprotein, commonly with Asp or Glu in the P6 position, Cys or Thr in P1 and Ser or Ala in P1'.

Autocatalytically cleaves itself from the polyprotein of the foot-and-mouth disease virus by hydrolysis of a Lys-|-Gly bond, but then cleaves host cell initiation factor eIF-4G at bonds -Gly-|-Arg- and -Lys-|-Arg-.

Nitric oxide + H(2)O + ferricytochrome c = nitrite + ferrocytochrome c + 2 H(+)

5-hydroxyisourate + H(2)O = 5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate

2 nitric oxide + 2 O(2) + NAD(P)H = 2 nitrate + NAD(P)(+) + H(+)

Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins

L-homoserine + NAD(P)(+) = L-aspartate 4-semialdehyde + NAD(P)H

N-acetyl-O-acetylneuraminate + H(2)O = N-acetylneuraminate + acetate

(S)-dihydroorotate + fumarate = orotate + succinate

Selective cleavage of Tyr-|-Gly bond in picornavirus polyprotein.

NTP + H(2)O = NDP + phosphate

4 benzenediol + O(2) = 4 benzosemiquinone + 2 H(2)O

1-haloalkane + H(2)O = a primary alcohol + halide

N-carbamoylputrescine + H(2)O = putrescine + CO(2) + NH(3)

Succinate semialdehyde + NAD(P)(+) + H(2)O = succinate + NAD(P)H

H(2)CO(3) = CO(2) + H(2)O

2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H(2)O = ribonucleoside diphosphate + thioredoxin

Selective cleavage of Gln-|-Gly bond in the poliovirus polyprotein. In other picornavirus reactions Glu may be substituted for Gln, and Ser or Thr for Gly.

Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides

Peptidylproline (omega=180) = peptidylproline (omega=0)

ATP + H(2)O = ADP + phosphate

4 Fe(2+) + 4 H(+) + O(2) = 4 Fe(3+) + 2 H(2)O

S-adenosyl-L-methionine + a catechol = S-adenosyl-L-homocysteine + a guaiacol

3'-end directed exonucleolytic cleavage of viral RNA-DNA hybrid

(2R)-2,3-dihydroxy-3-methylbutanoate + NADP(+) = (2S)-2-hydroxy-2-methyl-3-oxobutanoate + NADPH

The C-O-P bond 3' to the apurinic or apyrimidinic site in DNA is broken by a beta-elimination reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate

Endohydrolysis of RNA in RNA/DNA hybrids. Three different cleavage modes: 1. sequence-specific internal cleavage of RNA. Human immunodeficiency virus type 1 and Moloney murine leukemia virus enzymes prefer to cleave the RNA strand one nucleotide away from the RNA-DNA junction. 2. RNA 5'-end directed cleavage 13-19 nucleotides from the RNA end. 3. DNA 3'-end directed cleavage 15-20 nucleotides away from the primer terminus.

Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1)

Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1)

L-asparagine + H(2)O = L-aspartate + NH(3)

L-lysyl-tRNA(Lys) + phosphatidylglycerol = tRNA(Lys) + 3-O-L-lysyl-1-O-phosphatidylglycerol