› 1l8r

X-ray diffraction
1.65Å resolution

Structure of the Retinal Determination Protein Dachshund Reveals a DNA-Binding Motif

Released:
DOI: 10.2210/pdb1l8r/pdb
PDB 1l8r coloured by chain and viewed from the front.
PDB 1l8r coloured by chain and viewed from the side.
PDB 1l8r coloured by chain and viewed from the top.
Source organism: Homo sapiens
Primary publication:
Structure of the retinal determination protein Dachshund reveals a DNA binding motif.
Kim SS, Zhang RG, Braunstein SE, Joachimiak A, Cvekl A, Hegde RS
Structure 10 787-95 (2002)
PMID: 12057194

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Dachshund homolog 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 101 amino acids
Theoretical weight: 11.29 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9UI36 (Residues: 184-282; Coverage: 13%)
Gene names: DACH, DACH1
Structure domains: Ski

Ligands and Environments

No bound ligands
1 modified residue:
Ligand MSE 2 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: P1
Unit cell:
a: 28.797Å b: 47.731Å c: 50.436Å
α: 60.75° β: 86.86° γ: 84.55°
R-values:
R R work R free
0.237 0.237 0.259
Expression system: Escherichia coli

Quick links

Citations

10 review citations

The DACH/EYA/SIX gene network and its role in tumor initiation and progression.
Liu et al. (2016)
9 more

5 mentions without citation

Dead-end elimination with perturbations (DEEPer): a provable protein design algorithm with continuous sidechain and backbone flexibility.
Hallen et al. (2013)
4 more