› 1l2g

X-ray diffraction
2.85Å resolution

Structure of a C-terminally truncated form of glycoprotein D from HSV-1

Released:
DOI: 10.2210/pdb1l2g/pdb
PDB 1l2g coloured by chain and viewed from the front.
PDB 1l2g coloured by chain and viewed from the side.
PDB 1l2g coloured by chain and viewed from the top.
Source organism: Human alphaherpesvirus 1
Primary publication:
Herpes simplex virus glycoprotein D bound to the human receptor HveA.
Carf�� A, Willis SH, Whitbeck JC, Krummenacher C, Cohen GH, Eisenberg RJ, Wiley DC
Mol. Cell 8 169-79 (2001)
PMID: 11511370

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assemblies composition:
homo dimer (preferred)
homo octamer
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Envelope glycoprotein D Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 287 amino acids
Theoretical weight: 31.84 KDa
Source organism: Human alphaherpesvirus 1
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P57083 (Residues: 26-310; Coverage: 77%)
Gene names: US6, gD
Sequence domains: Herpesvirus glycoprotein D/GG/GX domain
Structure domains: Glycoprotein D; Chain: A;

Ligands and Environments

1 bound ligand:
Ligand NAG 4 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X25
Spacegroup: P4
Unit cell:
a: 131.416Å b: 131.416Å c: 83.265Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.288 0.278 0.297
Expression system: Spodoptera frugiperda

Quick links

Citations

54 review citations

Programmed Cell Death-Dependent Host Defense in Ocular Herpes Simplex Virus Infection.
Guo et al. (2022)
53 more

9 mentions without citation

Fusing structure and function: a structural view of the herpesvirus entry machinery.
Connolly et al. (2011)
8 more