Function and Biology

Crystal structure of NusA from Thermotoga maritima: a structure-based role of the N-terminal domain

Source organism: Thermotoga maritima
Biochemical function: nucleic acid binding
Biological process: regulation of DNA-templated transcription, termination
Cellular component: cytosol

Sequence families

Pfam Protein families (Pfam)
PF00575
Domain description: S1 RNA binding domain
Occurring in:
  1. Transcription termination/antitermination protein NusA
1 copy of Pfam domain PF00575 (S1 RNA binding domain) in Transcription termination/antitermination protein NusA in PDB 1l2f.

PF08529
Domain description: NusA N-terminal domain
Occurring in:
  1. Transcription termination/antitermination protein NusA
1 copy of Pfam domain PF08529 (NusA N-terminal domain) in Transcription termination/antitermination protein NusA in PDB 1l2f.

PF13184
Domain description: NusA-like KH domain
Occurring in:
  1. Transcription termination/antitermination protein NusA
1 copy of Pfam domain PF13184 (NusA-like KH domain) in Transcription termination/antitermination protein NusA in PDB 1l2f.

InterPro InterPro annotations
IPR009019
Domain description: K homology domain superfamily, prokaryotic type
Occurring in:
  1. Transcription termination/antitermination protein NusA
IPR015946
Domain description: K homology domain-like, alpha/beta
Occurring in:
  1. Transcription termination/antitermination protein NusA
IPR025249
Domain description: KH domain, NusA-like
Occurring in:
  1. Transcription termination/antitermination protein NusA
IPR013735
Domain description: Transcription factor NusA, N-terminal
Occurring in:
  1. Transcription termination/antitermination protein NusA
IPR010213
Domain description: Transcription termination factor NusA
Occurring in:
  1. Transcription termination/antitermination protein NusA
IPR003029
Domain description: S1 domain
Occurring in:
  1. Transcription termination/antitermination protein NusA
IPR022967
Domain description: RNA-binding domain, S1
Occurring in:
  1. Transcription termination/antitermination protein NusA
IPR012340
Domain description: Nucleic acid-binding, OB-fold
Occurring in:
  1. Transcription termination/antitermination protein NusA
IPR030842
Domain description: Transcription termination/antitermination protein NusA, bacterial
Occurring in:
  1. Transcription termination/antitermination protein NusA
IPR036555
Domain description: NusA, N-terminal domain superfamily
Occurring in:
  1. Transcription termination/antitermination protein NusA

Structure domains

CATH CATH domains
3.30.300.20
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: GMP Synthetase; Chain A, domain 3
Homology: GMP Synthetase; Chain A, domain 3
Occurring in:
  1. Transcription termination/antitermination protein NusA
2 copies of CATH domain 3.30.300.20 (GMP Synthetase; Chain A, domain 3) in Transcription termination/antitermination protein NusA in PDB 1l2f.
3.30.1480.10
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: N Utilization Substance Protein A; Chain:P; domain 4
Homology: NusA, N-terminal domain
Occurring in:
  1. Transcription termination/antitermination protein NusA
1 copy of CATH domain 3.30.1480.10 (N Utilization Substance Protein A; Chain:P; domain 4) in Transcription termination/antitermination protein NusA in PDB 1l2f.
2.40.50.140
Class: Mainly Beta
Architecture: Beta Barrel
Topology: OB fold (Dihydrolipoamide Acetyltransferase, E2P)
Homology: Nucleic acid-binding proteins
Occurring in:
  1. Transcription termination/antitermination protein NusA
1 copy of CATH domain 2.40.50.140 (OB fold (Dihydrolipoamide Acetyltransferase, E2P)) in Transcription termination/antitermination protein NusA in PDB 1l2f.
SCOP SCOP annotations
54815
Class: Alpha and beta proteins (a+b)
Fold: Alpha-lytic protease prodomain-like
Superfamily: Prokaryotic type KH domain (KH-domain type II)
Occurring in:
  1. Transcription termination/antitermination protein NusA
2 copies of SCOP domain 54815 (Prokaryotic type KH domain (KH-domain type II)) in Transcription termination/antitermination protein NusA in PDB 1l2f.
69706
Class: Alpha and beta proteins (a+b)
Fold: Transcription factor NusA, N-terminal domain
Superfamily: Transcription factor NusA, N-terminal domain
Occurring in:
  1. Transcription termination/antitermination protein NusA
1 copy of SCOP domain 69706 (Transcription factor NusA, N-terminal domain) in Transcription termination/antitermination protein NusA in PDB 1l2f.