› 1kwa

X-ray diffraction
1.93Å resolution

HUMAN CASK/LIN-2 PDZ DOMAIN

Released:
DOI: 10.2210/pdb1kwa/pdb
PDB entry 1kwa coloured by chain, front view.
PDB entry 1kwa coloured by chain, side view.
PDB entry 1kwa coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of the hCASK PDZ domain reveals the structural basis of class II PDZ domain target recognition.
Daniels DL, Cohen AR, Anderson JM, Brünger AT
Nat Struct Biol 5 317-25 (1998)
PMID: 9546224

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo tetramer
homo dimer
Assembly name:
PDBe Complex ID:
PDB-CPX-127208 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Peripheral plasma membrane protein CASK Chains: A, B
Molecule details ›
Chains: A, B
Length: 88 amino acids
Theoretical weight: 10.19 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O14936 (Residues: 487-572; Coverage: 9%)
Gene names: CASK, LIN2
Sequence domains: PDZ domain
Structure domains: Pdz3 Domain

Ligands and Environments

1 bound ligand:
Ligand SO4 3 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL1-5
Spacegroup: C2221
Unit cell:
a: 40.8Å b: 97Å c: 92Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.251 0.251 0.298
Expression system: Escherichia coli

Quick links

Citations

20 review citations

PDZ domains and the organization of supramolecular complexes.
Sheng et al. (2001)
19 more

13 mentions without citation

Neuroligins and neurexins link synaptic function to cognitive disease.
Südhof TC. (2008)
12 more