X-ray diffraction
1.8Å resolution

X-ray Crystallographic Studies of Serotonin N-acetyltransferase Catalysis and Inhibition


Function and Biology Details

Reaction catalysed:
Acetyl-CoA + a 2-arylethylamine = CoA + an N-acetyl-2-arylethylamine
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Serotonin N-acetyltransferase Chain: A
Molecule details ›
Chain: A
Length: 207 amino acids
Theoretical weight: 23.11 KDa
Source organism: Ovis aries
Expression system: Escherichia coli
  • Canonical: Q29495 (Residues: 1-207; Coverage: 100%)
Gene names: AANAT, SNAT
Sequence domains: Acetyltransferase (GNAT) family
Structure domains: Aminopeptidase

Ligands and Environments

Cofactor: Ligand CA3 1 x CA3
No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: CHESS BEAMLINE A1
Spacegroup: C2221
Unit cell:
a: 53.455Å b: 68.567Å c: 89.791Å
α: 90° β: 90° γ: 90°
R R work R free
0.2 0.197 0.225
Expression system: Escherichia coli