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X-ray Crystallographic Studies of Serotonin N-acetyltransferase Catalysis and Inhibition

Source organism: Ovis aries
Biochemical function: acyltransferase activity, transferring groups other than amino-acyl groups
Biological process: cellular response to cAMP
Cellular component: perinuclear region of cytoplasm

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EC 2.3.1.87: Aralkylamine N-acetyltransferase

Reaction catalysed:
Acetyl-CoA + a 2-arylethylamine = CoA + an N-acetyl-2-arylethylamine
Systematic name:
Acetyl-CoA:2-arylethylamine N-acetyltransferase
Alternative Name(s):
  • AANAT
  • Arylalkylamine N-acetyltransferase
  • Melatonin rhythm enzyme
  • Serotonin N-acetyltransferase
  • Serotonin acetylase
  • Serotonin acetyltransferase

GO terms

Sequence family

Pfam Protein family (Pfam)
PF00583
Domain description: Acetyltransferase (GNAT) family
Occurring in:
  1. Serotonin N-acetyltransferase
The deposited structure of PDB entry 1kuv contains 1 copy of Pfam domain PF00583 (Acetyltransferase (GNAT) family) in Serotonin N-acetyltransferase. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR000182
Domain description: GNAT domain
Occurring in:
  1. Serotonin N-acetyltransferase
IPR016181
Domain description: Acyl-CoA N-acyltransferase
Occurring in:
  1. Serotonin N-acetyltransferase

Structure domain

CATH CATH domain
3.40.630.30
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Aminopeptidase
Homology: Aminopeptidase
Occurring in:
  1. Serotonin N-acetyltransferase
The deposited structure of PDB entry 1kuv contains 1 copy of CATH domain 3.40.630.30 (Aminopeptidase) in Serotonin N-acetyltransferase. Showing 1 copy in chain A.
SCOP SCOP annotation
55730
Class: Alpha and beta proteins (a+b)
Fold: Acyl-CoA N-acyltransferases (Nat)
Superfamily: Acyl-CoA N-acyltransferases (Nat)
Occurring in:
  1. Serotonin N-acetyltransferase
The deposited structure of PDB entry 1kuv contains 1 copy of SCOP domain 55730 (N-acetyl transferase, NAT) in Serotonin N-acetyltransferase. Showing 1 copy in chain A.

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