X-ray diffraction
2.5Å resolution

Fasciculin 2-Mouse Acetylcholinesterase Complex


Function and Biology Details

Reaction catalysed:
Acetylcholine + H(2)O = choline + acetate
Biochemical function:
Cellular component:

Structure analysis Details

Assemblies composition:
hetero dimer (preferred)
hetero tetramer
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Acetylcholinesterase Chain: A
Molecule details ›
Chain: A
Length: 549 amino acids
Theoretical weight: 60.41 KDa
Source organism: Mus musculus
Expression system: Homo sapiens
  • Canonical: P21836 (Residues: 32-580; Coverage: 94%)
Gene name: Ache
Sequence domains: Carboxylesterase family
Structure domains: alpha/beta hydrolase
Fasciculin-2 Chain: B
Molecule details ›
Chain: B
Length: 61 amino acids
Theoretical weight: 6.77 KDa
Source organism: Dendroaspis angusticeps
  • Canonical: P0C1Z0 (Residues: 1-61; Coverage: 100%)
Structure domains: CD59

Ligands and Environments

2 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-3
Spacegroup: P6522
Unit cell:
a: 73.8Å b: 73.8Å c: 548.62Å
α: 90° β: 90° γ: 120°
R R work R free
0.226 0.226 0.273
Expression system: Homo sapiens