1ktz

X-ray diffraction
2.15Å resolution

Crystal Structure of the Human TGF-beta Type II Receptor Extracellular Domain in Complex with TGF-beta3

Released:
Source organism: Homo sapiens
Primary publication:
Crystal structure of the human TbetaR2 ectodomain--TGF-beta3 complex.
Nat. Struct. Biol. 9 203-8 (2002)
PMID: 11850637

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Transforming growth factor beta-3 Chain: A
Molecule details ›
Chain: A
Length: 112 amino acids
Theoretical weight: 12.73 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P10600 (Residues: 301-412; Coverage: 29%)
Gene name: TGFB3
Sequence domains: Transforming growth factor beta like domain
Structure domains: Cystine-knot cytokines
TGF-beta receptor type-2 Chain: B
Molecule details ›
Chain: B
Length: 122 amino acids
Theoretical weight: 13.85 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P37173 (Residues: 38-159; Coverage: 22%)
Gene name: TGFBR2
Sequence domains: Transforming growth factor beta receptor 2 ectodomain
Structure domains: CD59

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X8C
Spacegroup: R32
Unit cell:
a: 114.41Å b: 114.41Å c: 209.43Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.201 0.201 0.215
Expression system: Escherichia coli