X-ray diffraction
2.65Å resolution

Crystal Structure of mycolic acid cyclopropane synthase CmaA2 complexed with SAH and DDDMAB


Function and Biology Details

Reaction catalysed:
S-adenosyl-L-methionine + phospholipid olefinic fatty acid = S-adenosyl-L-homocysteine + phospholipid cyclopropane fatty acid
Biochemical function:
Cellular component:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo dimer
Entry contents:
1 distinct polypeptide molecule
Cyclopropane mycolic acid synthase 2 Chain: A
Molecule details ›
Chain: A
Length: 302 amino acids
Theoretical weight: 34.64 KDa
Source organism: Mycobacterium tuberculosis
Expression system: Escherichia coli BL21(DE3)
  • Canonical: P9WPB5 (Residues: 1-302; Coverage: 100%)
Gene names: CMAS-2, MTCY20G9.30c, Rv0503c, cma2, cmaA2
Sequence domains: Mycolic acid cyclopropane synthetase
Structure domains: Vaccinia Virus protein VP39

Ligands and Environments

Cofactor: Ligand SAH 1 x SAH
3 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 14-BM-C
Spacegroup: I4122
Unit cell:
a: 106.71Å b: 106.71Å c: 227.498Å
α: 90° β: 90° γ: 90°
R R work R free
0.208 0.208 0.242
Expression system: Escherichia coli BL21(DE3)