Function and Biology

The Mad2 Spindle Checkpoint Protein Undergoes Similar Major Conformational Changes upon Binding to Either Mad1 or Cdc20

Sequence family

Pfam Protein family (Pfam)
PF02301
Domain description: HORMA domain
Occurring in:
  1. Mitotic spindle assembly checkpoint protein MAD2A
The deposited structure of PDB entry 1klq contains 1 copy of Pfam domain PF02301 (HORMA domain) in Mitotic spindle assembly checkpoint protein MAD2A. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR003511
Domain description: HORMA domain
Occurring in:
  1. Mitotic spindle assembly checkpoint protein MAD2A
IPR036570
Domain description: HORMA domain superfamily
Occurring in:
  1. Mitotic spindle assembly checkpoint protein MAD2A
IPR045091
Domain description: Mad2-like
Occurring in:
  1. Mitotic spindle assembly checkpoint protein MAD2A

Structure domain

CATH CATH domain
3.30.900.10
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: Cell Cycle, Spindle Assembly Checkpoint Protein; Chain A
Homology: HORMA domain
Occurring in:
  1. Mitotic spindle assembly checkpoint protein MAD2A
The deposited structure of PDB entry 1klq contains 1 copy of CATH domain 3.30.900.10 (Cell Cycle, Spindle Assembly Checkpoint Protein; Chain A) in Mitotic spindle assembly checkpoint protein MAD2A. Showing 1 copy in chain A.
SCOP SCOP annotation
56020
Class: Alpha and beta proteins (a+b)
Fold: The spindle assembly checkpoint protein mad2
Superfamily: The spindle assembly checkpoint protein mad2
Occurring in:
  1. Mitotic spindle assembly checkpoint protein MAD2A
The deposited structure of PDB entry 1klq contains 1 copy of SCOP domain 56020 (The spindle assembly checkpoint protein mad2) in Mitotic spindle assembly checkpoint protein MAD2A. Showing 1 copy in chain A.