1kku

X-ray diffraction
2.5Å resolution

Crystal structure of nuclear human nicotinamide mononucleotide adenylyltransferase

Released:

Function and Biology Details

Reactions catalysed:
ATP + nicotinamide ribonucleotide = diphosphate + NAD(+)
ATP + beta-nicotinate-D-ribonucleotide = diphosphate + deamido-NAD(+)
Biochemical function:
Cellular component:

Structure analysis Details

Assembly composition:
homo hexamer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1 Chain: A
Molecule details ›
Chain: A
Length: 279 amino acids
Theoretical weight: 32.02 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9HAN9 (Residues: 1-279; Coverage: 100%)
Gene names: NMNAT, NMNAT1
Sequence domains: Cytidylyltransferase-like
Structure domains: HUPs

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-1
Spacegroup: P6322
Unit cell:
a: 147.459Å b: 147.459Å c: 61.71Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.25 0.236 0.284
Expression system: Escherichia coli BL21(DE3)