1kcg

X-ray diffraction
2.6Å resolution

NKG2D in complex with ULBP3

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
Non-polymer only trimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
NKG2-D type II integral membrane protein Chains: A, B
Molecule details ›
Chains: A, B
Length: 124 amino acids
Theoretical weight: 14.37 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P26718 (Residues: 93-216; Coverage: 57%)
Gene names: D12S2489E, KLRK1, NKG2D
Sequence domains: Lectin C-type domain
Structure domains: Mannose-Binding Protein A, subunit A
UL16-binding protein 3 Chain: C
Molecule details ›
Chain: C
Length: 178 amino acids
Theoretical weight: 21.13 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9BZM4 (Residues: 30-207; Coverage: 83%)
Gene names: N2DL3, RAET1N, ULBP3
Sequence domains: Class I Histocompatibility antigen, domains alpha 1 and 2
Structure domains: MHC class I-like antigen recognition-like

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X9B
Spacegroup: P43212
Unit cell:
a: 62.05Å b: 62.05Å c: 237.31Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.22 0.22 0.268
Expression system: Escherichia coli