Structure analysis

Crystal Structure of VDR DNA-binding Domain Bound to Mouse Osteopontin (SPP) Response Element

X-ray diffraction
2.7Å resolution
Source organism: Homo sapiens
Assembly composition:
hetero tetramer (preferred)
Entry contents: 1 distinct polypeptide molecule
2 distinct DNA molecules

Assemblies

Assembly 1 (preferred)
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Multimeric state: hetero tetramer
Accessible surface area: 15200 Å2
Buried surface area: 5300 Å2
Dissociation area: 1,100 Å2
Dissociation energy (ΔGdiss): 11 kcal/mol
Dissociation entropy (TΔSdiss): 12 kcal/mol
Interface energy (ΔGint): -34 kcal/mol
Symmetry number: 1

Macromolecules

Chains: A, B
Length: 110 amino acids
Theoretical weight: 12.95 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P11473 (Residues: 16-125; Coverage: 26%)
Gene names: NR1I1, VDR
Pfam: Zinc finger, C4 type (two domains)
InterPro:
CATH: Erythroid Transcription Factor GATA-1, subunit A
SCOP: Nuclear receptor

Search similar proteins

Name: 5'-D(*CP*AP*CP*GP*GP*TP*TP*CP*AP*CP*GP*AP*GP*GP*TP*TP*CP*A)-3'
Representative chains: C
Source organism: Homo sapiens [9606]
Expression system: Not provided
Length: 18 nucleotides
Theoretical weight: 5.52 KDa

Search similar DNA

Name: 5'-D(*TP*GP*AP*AP*CP*CP*TP*CP*GP*TP*GP*AP*AP*CP*CP*GP*TP*G)-3'
Representative chains: D
Source organism: Homo sapiens [9606]
Expression system: Not provided
Length: 18 nucleotides
Theoretical weight: 5.52 KDa

Search similar DNA