Solution NMR

Solution Structure of a Phage-Derived Peptide Antagonist in Complex with Vascular Endothelial Growth Factor


Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Vascular endothelial growth factor A Chains: V, W
Molecule details ›
Chains: V, W
Length: 99 amino acids
Theoretical weight: 11.65 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
  • Canonical: P15692 (Residues: 37-135; Coverage: 48%)
Gene names: VEGF, VEGFA
Sequence domains: PDGF/VEGF domain
Structure domains: Cystine-knot cytokines
Phage-Derived Peptide Antagonist Chains: X, Y
Molecule details ›
Chains: X, Y
Length: 19 amino acids
Theoretical weight: 2.35 KDa
Source organism: Homo sapiens
Expression system: Not provided

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: Torsion angle dynamics simulated annealing
Expression systems:
  • Escherichia coli
  • Not provided