› 1k9a

X-ray diffraction
2.5Å resolution

Crystal structure analysis of full-length carboxyl-terminal Src kinase at 2.5 A resolution

Released:
DOI: 10.2210/pdb1k9a/pdb
PDB 1k9a coloured by chain and viewed from the front.
PDB 1k9a coloured by chain and viewed from the side.
PDB 1k9a coloured by chain and viewed from the top.
Source organism: Rattus norvegicus
Primary publication:
Structure of the carboxyl-terminal Src kinase, Csk.
Ogawa A, Takayama Y, Sakai H, Chong KT, Takeuchi S, Nakagawa A, Nada S, Okada M, Tsukihara T
J. Biol. Chem. 277 14351-4 (2002)
PMID: 11884384

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domains:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo dimer
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tyrosine-protein kinase CSK Chains: A, B, C, D, E, F
Molecule details ›
Chains: A, B, C, D, E, F
Length: 450 amino acids
Theoretical weight: 50.81 KDa
Source organism: Rattus norvegicus
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P32577 (Residues: 1-450; Coverage: 100%)
Gene name: Csk
Sequence domains:
Structure domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SPRING-8 BEAMLINE BL44XU
Spacegroup: P212121
Unit cell:
a: 115Å b: 162.6Å c: 232.4Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.246 0.246 0.288
Expression system: Spodoptera frugiperda

Quick links

Citations

21 review citations

How the Discovery of the CD4/CD8-p56lck Complexes Changed Immunology and Immunotherapy.
Rudd CE. (2021)
20 more

30 mentions without citation

The Src module: an ancient scaffold in the evolution of cytoplasmic tyrosine kinases.
Shah et al. (2018)
29 more