X-ray diffraction
1.75Å resolution

The L-histidinol dehydrogenase (hisD) structure implicates domain swapping and gene duplication.


Function and Biology Details

Reaction catalysed:
L-histidinol + H(2)O + 2 NAD(+) = L-histidine + 2 NADH
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Histidinol dehydrogenase Chains: A, B
Molecule details ›
Chains: A, B
Length: 434 amino acids
Theoretical weight: 46.43 KDa
Source organism: Escherichia coli
Expression system: Escherichia coli
  • Canonical: P06988 (Residues: 1-434; Coverage: 100%)
Gene names: JW2002, b2020, hisD
Sequence domains: Histidinol dehydrogenase
Structure domains:

Ligands and Environments

2 bound ligands:
1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X8C
Spacegroup: P212121
Unit cell:
a: 54.37Å b: 107.52Å c: 157.2Å
α: 90° β: 90° γ: 90°
R R work R free
0.19 0.19 0.225
Expression system: Escherichia coli