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Crystal Structure of the Acyl-homoserinelactone Synthase EsaI Complexed with Rhenate

Source organism: Pantoea stewartii subsp. stewartii
Biochemical function: N-acyl homoserine lactone synthase activity
Biological process: quorum sensing
Cellular component: not assigned

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EC 2.3.1.184: Acyl-homoserine-lactone synthase

Reaction catalysed:
An acyl-[acyl-carrier-protein] + S-adenosyl-L-methionine = [acyl-carrier-protein] + S-methyl-5'-thioadenosine + an N-acyl-L-homoserine lactone
Systematic name:
Acyl-[acy-carrier protein]:S-adenosyl-L-methionine acyltranserase (lactone-forming, methylthioadenosine-releasing)
Alternative Name(s):
  • AHL synthase
  • AHS
  • AHSL synthase
  • Acyl homoserine lactone synthase
  • Acyl-homoserine lactone synthase
  • Acyl-homoserinelactone synthase
  • Acylhomoserine lactone synthase
  • AhyI
  • AinS
  • AinS protein
  • Autoinducer synthase
  • Autoinducer synthesis protein
  • Autoinducer synthesis protein rhlI
  • EsaI
  • ExpISCC1
  • ExpISCC3065
  • LasI
  • LasR
  • LuxI
  • LuxI protein
  • LuxM
  • N-acyl homoserine lactone synthase
  • RhlI
  • YspI

GO terms

Biochemical function:
Biological process:
Cellular component:
  • not assigned

Sequence family

Pfam Protein family (Pfam)
PF00765
Domain description: Autoinducer synthase
Occurring in:
  1. Acyl-homoserine-lactone synthase
The deposited structure of PDB entry 1k4j contains 1 copy of Pfam domain PF00765 (Autoinducer synthase) in Acyl-homoserine-lactone synthase. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR001690
Domain description: Autoinducer synthase
Occurring in:
  1. Acyl-homoserine-lactone synthase
IPR018311
Domain description: Autoinducer synthesis, conserved site
Occurring in:
  1. Acyl-homoserine-lactone synthase
IPR016181
Domain description: Acyl-CoA N-acyltransferase
Occurring in:
  1. Acyl-homoserine-lactone synthase
IPR014729
Domain description: Rossmann-like alpha/beta/alpha sandwich fold
Occurring in:
  1. Acyl-homoserine-lactone synthase

Structure domain

CATH CATH domain
3.40.630.30
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Aminopeptidase
Homology: Aminopeptidase
Occurring in:
  1. Acyl-homoserine-lactone synthase
The deposited structure of PDB entry 1k4j contains 1 copy of CATH domain 3.40.630.30 (Aminopeptidase) in Acyl-homoserine-lactone synthase. Showing 1 copy in chain A.
SCOP SCOP annotation
75508
Class: Alpha and beta proteins (a+b)
Fold: Acyl-CoA N-acyltransferases (Nat)
Superfamily: Acyl-CoA N-acyltransferases (Nat)
Occurring in:
  1. Acyl-homoserine-lactone synthase
The deposited structure of PDB entry 1k4j contains 1 copy of SCOP domain 75508 (Autoinducer synthetase) in Acyl-homoserine-lactone synthase. Showing 1 copy in chain A.

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