› 1k44

X-ray diffraction
2.6Å resolution

Mycobacterium tuberculosis Nucleoside Diphosphate Kinase

Released:
DOI: 10.2210/pdb1k44/pdb
PDB entry 1k44 coloured by chain, front view.
PDB entry 1k44 coloured by chain, side view.
PDB entry 1k44 coloured by chain, top view.
Source organism: Mycobacterium tuberculosis
Primary publication:
X-ray structure of Mycobacterium tuberculosis nucleoside diphosphate kinase.
Chen Y, Morera S, Mocan J, Lascu I, Janin J
Proteins 47 556-7 (2002)
PMID: 12001234

Function and Biology Details

Reaction catalysed: 
ATP + nucleoside diphosphate = ADP + nucleoside triphosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo hexamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-161690 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Nucleoside diphosphate kinase Chains: A, B, C, D, E, F
Molecule details ›
Chains: A, B, C, D, E, F
Length: 136 amino acids
Theoretical weight: 14.52 KDa
Source organism: Mycobacterium tuberculosis
Expression system: Escherichia coli
UniProt:
  • Canonical: P9WJH7 (Residues: 1-136; Coverage: 100%)
Gene names: MTCY428.01, MTV008.01c, Rv2445c, ndk, ndkA
Sequence domains: Nucleoside diphosphate kinase
Structure domains: Nucleoside diphosphate kinase-like domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU
Spacegroup: P212121
Unit cell:
a: 77.033Å b: 98.818Å c: 127.52Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.205 0.205 0.246
Expression system: Escherichia coli

Quick links

Citations

2 review citations

Structure, Folding and Stability of Nucleoside Diphosphate Kinases.
Georgescauld et al. (2020)
1 more

5 mentions without citation

Nucleoside diphosphate kinase from Mycobacterium tuberculosis cleaves single strand DNA within the human c-myc promoter in an enzyme-catalyzed reaction.
Kumar et al. (2005)
4 more