1k40

X-ray diffraction
2.25Å resolution

crystal structure of the FAT domain of focal adhesion kinase

Released:

Function and Biology Details

Reaction catalysed:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Focal adhesion kinase 1 Chain: A
Molecule details ›
Chain: A
Length: 126 amino acids
Theoretical weight: 14.01 KDa
Source organism: Mus musculus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P34152 (Residues: 921-1046; Coverage: 12%)
Gene names: Fadk, Fak, Fak1, Kiaa4203, Ptk2
Structure domains: Nucleotidyltransferases domain 2

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X26C
Spacegroup: C2
Unit cell:
a: 61.104Å b: 40.163Å c: 52.008Å
α: 90° β: 103.82° γ: 90°
R-values:
R R work R free
0.236 0.236 0.294
Expression system: Escherichia coli BL21(DE3)