X-ray diffraction
1.95Å resolution

Structure of Glycosomal Glyceraldehyde-3-Phosphate Dehydrogenase from Trypanosoma cruzi Complexed with Chalepin, a Coumarin Derivative Inhibitor


Function and Biology Details

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Entry contents:
1 distinct polypeptide molecule
Glyceraldehyde-3-phosphate dehydrogenase, glycosomal Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 359 amino acids
Theoretical weight: 39.11 KDa
Source organism: Trypanosoma cruzi
Expression system: Escherichia coli
  • Canonical: P22513 (Residues: 1-359; Coverage: 100%)
Sequence domains:
Structure domains:

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU200
Spacegroup: P21
Unit cell:
a: 82.08Å b: 84.97Å c: 105.24Å
α: 90° β: 96.32° γ: 90°
R R work R free
0.201 0.201 0.28
Expression system: Escherichia coli