X-ray diffraction
2.1Å resolution

Structure of the Insulin-like Growth Factor 1 Receptor Kinase

Source organism: Homo sapiens
Entry authors: Favelyukis S, Till JH, Hubbard SR, Miller WT

Function and Biology Details

Reaction catalysed:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Insulin-like growth factor 1 receptor beta chain Chain: A
Molecule details ›
Chain: A
Length: 299 amino acids
Theoretical weight: 34.41 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
  • Canonical: P08069 (Residues: 988-1286; Coverage: 22%)
Gene name: IGF1R
Sequence domains: Protein tyrosine and serine/threonine kinase
Structure domains:
Insulin receptor substrate 1 Chain: B
Molecule details ›
Chain: B
Length: 14 amino acids
Theoretical weight: 1.6 KDa
Source organism: Homo sapiens
Expression system: Not provided
  • Canonical: P35568 (Residues: 889-902; Coverage: 1%)
Gene name: IRS1

Ligands and Environments

1 bound ligand:
1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X4A
Spacegroup: C2221
Unit cell:
a: 80.624Å b: 111.018Å c: 93.297Å
α: 90° β: 90° γ: 90°
R R work R free
0.212 0.212 0.251
Expression systems:
  • Spodoptera frugiperda
  • Not provided