X-ray diffraction
2.5Å resolution

Crystal Structure Analysis of the SH2 Domain of the Csk Homologous Kinase CHK

Source organism: Homo sapiens
Entry authors: Murthy TVS, Webster GD

Function and Biology Details

Reaction catalysed:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Megakaryocyte-associated tyrosine-protein kinase Chain: A
Molecule details ›
Chain: A
Length: 97 amino acids
Theoretical weight: 11.2 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
  • Canonical: P42679 (Residues: 117-213; Coverage: 19%)
Gene names: CTK, HYL, MATK
Sequence domains: SH2 domain
Structure domains: SH2 domain

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU300
Spacegroup: C2
Unit cell:
a: 64.146Å b: 58.696Å c: 28.817Å
α: 90° β: 115.36° γ: 90°
R R work R free
0.194 0.191 0.257
Expression system: Escherichia coli BL21(DE3)