Function and Biology

P27(KIP1)/CYCLIN A/CDK2 COMPLEX

Source organism: Homo sapiens
Biochemical function: protein binding
Biological process: cellular response to nitric oxide
Cellular component: nucleus

EC 2.7.11.22: Cyclin-dependent kinase

Reaction catalysed:
ATP + a protein = ADP + a phosphoprotein
Systematic name:
ATP:cyclin phosphotransferase
Alternative Name(s):
  • Bur1
  • Bur1 Cdk
  • CDK
  • Cak1
  • Cak1p
  • Cdc2
  • Cdc2 kinase
  • Cdc28p
  • Cdk-activating kinase
  • Cdk-activating protein kinase
  • Cdk1
  • Cdk2
  • Cdk2
  • Cdk3
  • Cdk4
  • Cdk5
  • Cdk6
  • Cdk7
  • Cdk8
  • Cdk9
  • Cyclin A-activated cdc2
  • Cyclin A-activated cdk2
  • Cyclin D-cdk6 kinase
  • Cyclin D-dependent kinase
  • Cyclin E kinase
  • Cyclin-A associated kinase
  • Cyclin-dependent kinase 6
  • Cyclin-dependent kinase-2
  • Cyclin-dependent kinase-4
  • Cyclin-dependent protein kinase activating kinase
  • Cyk
  • D-type cyclin kinase
  • Nclk
  • Neuronal cdc2-like kinase
  • PCTAIRE-1
  • STK25

Sequence families

Pfam Protein families (Pfam)
PF00069
Domain description: Protein kinase domain
Occurring in:
  1. Cyclin-dependent kinase 2
1 copy of Pfam domain PF00069 (Protein kinase domain) in Cyclin-dependent kinase 2 in PDB 1jsu.

PF00134
Domain description: Cyclin, N-terminal domain
Occurring in:
  1. Cyclin-A2
1 copy of Pfam domain PF00134 (Cyclin, N-terminal domain) in Cyclin-A2 in PDB 1jsu.

PF02984
Domain description: Cyclin, C-terminal domain
Occurring in:
  1. Cyclin-A2
1 copy of Pfam domain PF02984 (Cyclin, C-terminal domain) in Cyclin-A2 in PDB 1jsu.

PF02234
Domain description: Cyclin-dependent kinase inhibitor
Occurring in:
  1. Cyclin-dependent kinase inhibitor 1B
1 copy of Pfam domain PF02234 (Cyclin-dependent kinase inhibitor) in Cyclin-dependent kinase inhibitor 1B in PDB 1jsu.

InterPro InterPro annotations
IPR013763
Domain description: Cyclin-like
Occurring in:
  1. Cyclin-A2
IPR003175
Domain description: Cyclin-dependent kinase inhibitor domain
Occurring in:
  1. Cyclin-dependent kinase inhibitor 1B
IPR004367
Domain description: Cyclin, C-terminal domain
Occurring in:
  1. Cyclin-A2
IPR039361
Domain description: Cyclin
Occurring in:
  1. Cyclin-A2
IPR036915
Domain description: Cyclin-like superfamily
Occurring in:
  1. Cyclin-A2
IPR006671
Domain description: Cyclin, N-terminal
Occurring in:
  1. Cyclin-A2
IPR029843
Domain description: Cyclin-dependent kinase inhibitor 1B
Occurring in:
  1. Cyclin-dependent kinase inhibitor 1B
IPR000719
Domain description: Protein kinase domain
Occurring in:
  1. Cyclin-dependent kinase 2
IPR011009
Domain description: Protein kinase-like domain superfamily
Occurring in:
  1. Cyclin-dependent kinase 2

Structure domains

CATH CATH domains
1.10.472.10
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: Cyclin A; domain 1
Homology: Cyclin-like
Occurring in:
  1. Cyclin-A2
2 copies of CATH domain 1.10.472.10 (Cyclin A; domain 1) in Cyclin-A2 in PDB 1jsu.
3.30.200.20
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: Phosphorylase Kinase; domain 1
Homology: Phosphorylase Kinase; domain 1
Occurring in:
  1. Cyclin-dependent kinase 2
1 copy of CATH domain 3.30.200.20 (Phosphorylase Kinase; domain 1) in Cyclin-dependent kinase 2 in PDB 1jsu.
4.10.365.10
Class: Few Secondary Structures
Architecture: Irregular
Topology: p27
Homology: p27
Occurring in:
  1. Cyclin-dependent kinase inhibitor 1B
1 copy of CATH domain 4.10.365.10 (p27) in Cyclin-dependent kinase inhibitor 1B in PDB 1jsu.
1.10.510.10
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: Transferase(Phosphotransferase); domain 1
Homology: Transferase(Phosphotransferase) domain 1
Occurring in:
  1. Cyclin-dependent kinase 2
1 copy of CATH domain 1.10.510.10 (Transferase(Phosphotransferase); domain 1) in Cyclin-dependent kinase 2 in PDB 1jsu.
SCOP SCOP annotations
47955
Class: All alpha proteins
Fold: Cyclin-like
Superfamily: Cyclin-like
Occurring in:
  1. Cyclin-A2
2 copies of SCOP domain 47955 (Cyclin) in Cyclin-A2 in PDB 1jsu.
88854
Class: Alpha and beta proteins (a+b)
Fold: Protein kinase-like (PK-like)
Superfamily: Protein kinase-like (PK-like)
Occurring in:
  1. Cyclin-dependent kinase 2
1 copy of SCOP domain 88854 (Protein kinases, catalytic subunit) in Cyclin-dependent kinase 2 in PDB 1jsu.
58674
Class: Peptides
Fold: P27(KIP1) fragment 22-106
Superfamily: P27(KIP1) fragment 22-106
Occurring in:
  1. Cyclin-dependent kinase inhibitor 1B
1 copy of SCOP domain 58674 (P27(KIP1) fragment 22-106) in Cyclin-dependent kinase inhibitor 1B in PDB 1jsu.