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P27(KIP1)/CYCLIN A/CDK2 COMPLEX

X-ray diffraction
2.3Å resolution
PDB entry 1jsu coloured by chain, front view.
PDB entry 1jsu coloured by chain, side view.
PDB entry 1jsu coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero trimer (preferred)
Entry contents: 3 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Cyclin A2-CDK2 complex and Cyclin-dependent kinase inhibitor 1B
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Multimeric state: hetero trimer
Accessible surface area: 24408.38 Å2
Buried surface area: 9192.86 Å2
Dissociation area: 2,794.99 Å2
Dissociation energy (ΔGdiss): 36.33 kcal/mol
Dissociation entropy (TΔSdiss): 12.62 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-148888

Macromolecules

Cyclin-dependent kinase 2
Chain: A
Length: 298 amino acids
Theoretical weight: 34.06 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P24941 (Residues: 1-298; Coverage: 100%)
Gene names: CDK2, CDKN2
Pfam: Protein kinase domain
InterPro:
CATH:
SCOP: Protein kinases, catalytic subunit
Cyclin-dependent kinase 2 in PDB entry 1jsu, assembly 1, front view.
Cyclin-dependent kinase 2 in PDB entry 1jsu, assembly 1, side view.
Cyclin-dependent kinase 2 in PDB entry 1jsu, assembly 1, top view.
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Cyclin-A2
Chain: B
Length: 260 amino acids
Theoretical weight: 29.87 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P20248 (Residues: 173-432; Coverage: 60%)
Gene names: CCN1, CCNA, CCNA2
Pfam:
InterPro:
CATH: Cyclin-like
SCOP: Cyclin
Cyclin-A2 in PDB entry 1jsu, assembly 1, front view.
Cyclin-A2 in PDB entry 1jsu, assembly 1, side view.
Cyclin-A2 in PDB entry 1jsu, assembly 1, top view.
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Cyclin-dependent kinase inhibitor 1B
Chain: C
Length: 84 amino acids
Theoretical weight: 9.97 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P46527 (Residues: 23-106; Coverage: 42%)
Gene names: CDKN1B, KIP1, p27
Pfam: Cyclin-dependent kinase inhibitor
InterPro:
CATH: p27
SCOP: P27(KIP1) fragment 22-106
Cyclin-dependent kinase inhibitor 1B in PDB entry 1jsu, assembly 1, front view.
Cyclin-dependent kinase inhibitor 1B in PDB entry 1jsu, assembly 1, side view.
Cyclin-dependent kinase inhibitor 1B in PDB entry 1jsu, assembly 1, top view.
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