1jpl

X-ray diffraction
2.4Å resolution

GGA3 VHS domain complexed with C-terminal peptide from cation-independent mannose 6-phosphate receptor

Released:

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assemblies composition:
Non-polymer only dimer (preferred)
Non-polymer only tetramer
Non-polymer only octamer
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
ADP-ribosylation factor-binding protein GGA3 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 171 amino acids
Theoretical weight: 19.72 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9NZ52 (Residues: 1-166; Coverage: 23%)
Gene names: GGA3, KIAA0154
Sequence domains: VHS domain
Structure domains: Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat
Cation-independent mannose-6-phosphate receptor Chains: E, F, G, H
Molecule details ›
Chains: E, F, G, H
Length: 12 amino acids
Theoretical weight: 1.46 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P11717 (Residues: 2480-2491; Coverage: 1%)
Gene names: IGF2R, MPRI

Ligands and Environments

No bound ligands
1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X9B
Spacegroup: P21212
Unit cell:
a: 108.3Å b: 125.3Å c: 64.6Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.213 0.213 0.257
Expression systems:
  • Escherichia coli BL21(DE3)
  • Not provided