1jpi

X-ray diffraction
2.3Å resolution

Phe232Leu mutant of human UROD, human uroporphyrinogen III decarboxylase

Released:

Function and Biology Details

Reaction catalysed:
Uroporphyrinogen III = coproporphyrinogen + 4 CO(2)

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Uroporphyrinogen decarboxylase Chain: A
Molecule details ›
Chain: A
Length: 388 amino acids
Theoretical weight: 43.33 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P06132 (Residues: 1-367; Coverage: 100%)
Gene name: UROD
Sequence domains: Uroporphyrinogen decarboxylase (URO-D)
Structure domains: TIM Barrel

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU
Spacegroup: P3121
Unit cell:
a: 103.32Å b: 103.32Å c: 72.031Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.2 0.2 0.243
Expression system: Escherichia coli