PDBe 1jdp

X-ray diffraction
2Å resolution

Crystal Structure of Hormone/Receptor Complex

Released:
Source organism: Homo sapiens

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Atrial natriuretic peptide receptor 3 Chains: A, B
Molecule details ›
Chains: A, B
Length: 441 amino acids
Theoretical weight: 49.54 KDa
Source organism: Homo sapiens
Expression system: Drosophila
UniProt:
  • Canonical: P17342 (Residues: 44-485; Coverage: 86%)
  • Best match: P17342-2 (Residues: 44-484)
Gene names: ANPRC, C5orf23, NPR3, NPRC
Sequence domains: Receptor family ligand binding region
Structure domains: Rossmann fold
CNP-22 Chain: H
Molecule details ›
Chain: H
Length: 22 amino acids
Theoretical weight: 2.2 KDa
Source organism: Homo sapiens
Expression system: Drosophila
UniProt:
  • Canonical: P23582 (Residues: 105-126; Coverage: 21%)
Gene names: CNP2, NPPC

Ligands and Environments

3 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL9-1
Spacegroup: P212121
Unit cell:
a: 56.8Å b: 136.455Å c: 137.591Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.227 0.227 0.248
Expression system: Drosophila