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Catalytic Domain of Human Phenylalanine Hydroxylase Fe(II) in Complex with Tetrahydrobiopterin

X-ray diffraction
1.5Å resolution
PDB entry 1j8u coloured by chain, front view.
PDB entry 1j8u coloured by chain, side view.
PDB entry 1j8u coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Phenylalanine-4-hydroxylase
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Multimeric state: homo dimer
Accessible surface area: 27029.11 Å2
Buried surface area: 2598.77 Å2
Dissociation area: 562.66 Å2
Dissociation energy (ΔGdiss): -6.86 kcal/mol
Dissociation entropy (TΔSdiss): 13.37 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-132487

Macromolecules

Phenylalanine-4-hydroxylase
Chain: A
Length: 325 amino acids
Theoretical weight: 37.6 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P00439 (Residues: 103-427; Coverage: 72%)
Gene name: PAH
Pfam: Biopterin-dependent aromatic amino acid hydroxylase
InterPro:
CATH: Aromatic amino acid hydroxylase
SCOP: Aromatic aminoacid monoxygenases, catalytic and oligomerization domains
Phenylalanine-4-hydroxylase in PDB entry 1j8u, assembly 1, front view.
Phenylalanine-4-hydroxylase in PDB entry 1j8u, assembly 1, side view.
Phenylalanine-4-hydroxylase in PDB entry 1j8u, assembly 1, top view.
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