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Osmolyte Stabilization of RNase

X-ray diffraction
2.3Å resolution
PDB entry 1j82 coloured by chain, front view.
PDB entry 1j82 coloured by chain, side view.
PDB entry 1j82 coloured by chain, top view.
Source organism: Bos taurus
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Ribonuclease pancreatic
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Multimeric state: hetero dimer
Accessible surface area: 6428.22 Å2
Buried surface area: 1739.24 Å2
Dissociation area: 731.55 Å2
Dissociation energy (ΔGdiss): 11.56 kcal/mol
Dissociation entropy (TΔSdiss): 8.07 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-158391

Macromolecules

Ribonuclease pancreatic
Chain: A
Length: 16 amino acids
Theoretical weight: 1.75 KDa
Source organism: Bos taurus
Expression system: Not provided
UniProt:
  • Canonical: P61823 (Residues: 27-41; Coverage: 12%)
Gene names: RNASE1, RNS1
SCOP: Ribonuclease A-like
Ribonuclease pancreatic in PDB entry 1j82, assembly 1, front view.
Ribonuclease pancreatic in PDB entry 1j82, assembly 1, side view.
Ribonuclease pancreatic in PDB entry 1j82, assembly 1, top view.
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Ribonuclease pancreatic
Chain: B
Length: 104 amino acids
Theoretical weight: 11.56 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: P61823 (Residues: 47-150; Coverage: 84%)
Gene names: RNASE1, RNS1
Pfam: Pancreatic ribonuclease
InterPro:
CATH: Ribonuclease A-like domain
SCOP: Ribonuclease A-like
Ribonuclease pancreatic in PDB entry 1j82, assembly 1, front view.
Ribonuclease pancreatic in PDB entry 1j82, assembly 1, side view.
Ribonuclease pancreatic in PDB entry 1j82, assembly 1, top view.
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