X-ray diffraction
2.3Å resolution

Osmolyte Stabilization of RNase


Function and Biology Details

Reaction catalysed:
(1a) an (RNA) containing cytidine = an (RNA)-3'-cytidine-2',3'-cyclophosphate + a 5'-hydroxy-ribonucleotide-3'-(RNA)
Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
Non-polymer only dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Ribonuclease pancreatic Chain: A
Molecule details ›
Chain: A
Length: 16 amino acids
Theoretical weight: 1.75 KDa
Source organism: Bos taurus
Expression system: Not provided
  • Canonical: P61823 (Residues: 27-41; Coverage: 12%)
Gene names: RNASE1, RNS1
Ribonuclease pancreatic Chain: B
Molecule details ›
Chain: B
Length: 104 amino acids
Theoretical weight: 11.56 KDa
Source organism: Bos taurus
  • Canonical: P61823 (Residues: 47-150; Coverage: 84%)
Gene names: RNASE1, RNS1
Structure domains: Ribonuclease A-like domain

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU200
Spacegroup: P3121
Unit cell:
a: 44.96Å b: 44.96Å c: 97.83Å
α: 90° β: 90° γ: 120°
R R work R free
0.203 0.189 0.256
Expression system: Not provided