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Structure of the extracellular aspartic proteinase from Candida tropicalis yeast.

Source organisms:
Biochemical function: aspartic-type endopeptidase activity
Biological process: proteolysis
Cellular component: extracellular region

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EC 3.4.23.24: Candidapepsin

Reaction catalysed:
Preferential cleavage at the carboxyl of hydrophobic amino acids, but fails to cleave 15-Leu-|-Tyr-16, 16-Tyr-|-Leu-17 and 24-Phe-|-Phe-25 of insulin B chain. Activates trypsinogen, and degrades keratin.
Systematic name:
-
Alternative Name(s):
  • Candida albicans aspartic proteinase
  • Candida albicans carboxyl proteinase
  • Candida albicans secretory acid proteinase
  • Candida aspartic proteinase
  • Candida olea acid proteinase
  • Candida olea aspartic proteinase

GO terms

Biochemical function:
Biological process:
Cellular component:

Sequence family

Pfam Protein family (Pfam)
PF00026
Domain description: Eukaryotic aspartyl protease
Occurring in:
  1. Candidapepsin
The deposited structure of PDB entry 1j71 contains 1 copy of Pfam domain PF00026 (Eukaryotic aspartyl protease) in Candidapepsin. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR001461
Domain description: Aspartic peptidase A1 family
Occurring in:
  1. Candidapepsin
IPR021109
Domain description: Aspartic peptidase domain superfamily
Occurring in:
  1. Candidapepsin
IPR033121
Domain description: Peptidase family A1 domain
Occurring in:
  1. Candidapepsin
IPR001969
Domain description: Aspartic peptidase, active site
Occurring in:
  1. Candidapepsin
IPR033876
Domain description: Secreted aspartic endopeptidase
Occurring in:
  1. Candidapepsin

Structure domain

CATH CATH domain
2.40.70.10
Class: Mainly Beta
Architecture: Beta Barrel
Topology: Cathepsin D, subunit A; domain 1
Homology: Acid Proteases
Occurring in:
  1. Candidapepsin
The deposited structure of PDB entry 1j71 contains 2 copies of CATH domain 2.40.70.10 (Cathepsin D, subunit A; domain 1) in Candidapepsin. Showing 2 copies in chain A.
SCOP SCOP annotation
50646
Class: All beta proteins
Fold: Acid proteases
Superfamily: Acid proteases
Occurring in:
  1. Candidapepsin
The deposited structure of PDB entry 1j71 contains 1 copy of SCOP domain 50646 (Pepsin-like) in Candidapepsin. Showing 1 copy in chain A.

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