X-ray diffraction
2.1Å resolution

Crystal structure of human Pirin: a Bcl-3 and Nuclear factor I interacting protein and a cupin superfamily member


Function and Biology Details

Reaction catalysed:
Quercetin + O(2) = 2-(3,4-dihydroxybenzoyloxy)-4,6-dihydroxybenzoate + CO + H(+)
Biochemical function:
Cellular component:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Pirin Chain: A
Molecule details ›
Chain: A
Length: 290 amino acids
Theoretical weight: 32.44 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
  • Canonical: O00625 (Residues: 1-290; Coverage: 100%)
Gene name: PIR
Sequence domains: Pirin C-terminal cupin domain
Structure domains: Jelly Rolls

Ligands and Environments

1 bound ligand:
1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: SPRING-8 BEAMLINE BL44B2
Spacegroup: P212121
Unit cell:
a: 42.278Å b: 67.116Å c: 106.389Å
α: 90° β: 90° γ: 90°
R R work R free
0.206 0.206 0.249
Expression system: Escherichia coli BL21(DE3)