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CRYSTAL STRUCTURE OF CBNR, A LYSR FAMILY TRANSCRIPTIONAL REGULATOR

Source organism: Cupriavidus necator
Biochemical function: DNA-binding transcription factor activity
Biological process: regulation of DNA-templated transcription
Cellular component: protein-DNA complex

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GO terms

Sequence families

Pfam Protein families (Pfam)
PF03466
Domain description: LysR substrate binding domain
Occurring in:
  1. HTH lysR-type domain-containing protein
The deposited structure of PDB entry 1iz1 contains 4 copies of Pfam domain PF03466 (LysR substrate binding domain) in HTH lysR-type domain-containing protein. Showing 1 copy in chain B.

PF00126
Domain description: Bacterial regulatory helix-turn-helix protein, lysR family
Occurring in:
  1. HTH lysR-type domain-containing protein
The deposited structure of PDB entry 1iz1 contains 4 copies of Pfam domain PF00126 (Bacterial regulatory helix-turn-helix protein, lysR family) in HTH lysR-type domain-containing protein. Showing 1 copy in chain B.

InterPro InterPro annotations
IPR000847
Domain description: Transcription regulator HTH, LysR
Occurring in:
  1. HTH lysR-type domain-containing protein
IPR005119
Domain description: LysR, substrate-binding
Occurring in:
  1. HTH lysR-type domain-containing protein
IPR036390
Domain description: Winged helix DNA-binding domain superfamily
Occurring in:
  1. HTH lysR-type domain-containing protein
IPR036388
Domain description: Winged helix-like DNA-binding domain superfamily
Occurring in:
  1. HTH lysR-type domain-containing protein

Structure domains

CATH CATH domains
3.40.190.10
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: D-Maltodextrin-Binding Protein; domain 2
Homology: Periplasmic binding protein-like II
Occurring in:
  1. HTH lysR-type domain-containing protein
The deposited structure of PDB entry 1iz1 contains 8 copies of CATH domain 3.40.190.10 (D-Maltodextrin-Binding Protein; domain 2) in HTH lysR-type domain-containing protein. Showing 2 copies in chain B.
1.10.10.10
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: Arc Repressor Mutant, subunit A
Homology: Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain
Occurring in:
  1. HTH lysR-type domain-containing protein
The deposited structure of PDB entry 1iz1 contains 4 copies of CATH domain 1.10.10.10 (Arc Repressor Mutant, subunit A) in HTH lysR-type domain-containing protein. Showing 1 copy in chain B.
SCOP SCOP annotations
53851
Class: Alpha and beta proteins (a/b)
Fold: Periplasmic binding protein-like II
Superfamily: Periplasmic binding protein-like II
Occurring in:
  1. HTH lysR-type domain-containing protein
The deposited structure of PDB entry 1iz1 contains 4 copies of SCOP domain 53851 (Phosphate binding protein-like) in HTH lysR-type domain-containing protein. Showing 1 copy in chain B.
88979
Class: All alpha proteins
Fold: DNA/RNA-binding 3-helical bundle
Superfamily: "Winged helix" DNA-binding domain
Occurring in:
  1. HTH lysR-type domain-containing protein
The deposited structure of PDB entry 1iz1 contains 4 copies of SCOP domain 88979 (LysR-like transcriptional regulators) in HTH lysR-type domain-containing protein. Showing 1 copy in chain B.

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