EC 3.2.2.6: ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase
Reaction catalysed:
(1a) NAD(+) = cyclic ADP-ribose + nicotinamide
Systematic name:
NAD(+) glycohydrolase (cyclic ADP-ribose-forming)
Alternative Name(s):
- BST1 (gene name)
- CD38 (gene name)
- DPN hydrolase
- DPNase
- NAD glycohydrolase
- NAD hydrolase
- NAD nucleosidase
- NAD(+) nucleosidase
- NADase
- Nicotinamide adenine dinucleotide glycohydrolase
- Nicotinamide adenine dinucleotide nucleosidase
GO terms
Biochemical function:
- interleukin-1, type I, activating receptor activity
- interleukin-1 receptor activity
- interleukin-1 type II receptor antagonist activity
- interleukin-1 type I receptor antagonist activity
- protein binding
- interleukin-1 receptor antagonist activity
- interleukin-1, type II receptor binding
- interleukin-1, type I receptor binding
- interleukin-1 receptor binding
- cytokine activity
Biological process:
Cellular component:
Sequence families
Protein families (Pfam)
![The deposited structure of PDB entry 1ira contains 1 copy of Pfam domain PF13895 (Immunoglobulin domain) in Interleukin-1 receptor type 1, soluble form. Showing 1 copy in chain B [auth Y].](https://www.ebi.ac.uk/pdbe/static/entry/1ira_2_Y_Pfam_PF13895_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>1ira</span> contains 1 copy of Pfam domain <span class='highlight'>PF13895 (Immunoglobulin domain)</span> in <span class='highlight'>Interleukin-1 receptor type 1, soluble form</span>. Showing 1 copy in chain <span class='highlight'>B [auth Y]</span>.")
![The deposited structure of PDB entry 1ira contains 1 copy of Pfam domain PF18452 (Immunoglobulin domain) in Interleukin-1 receptor type 1, soluble form. Showing 1 copy in chain B [auth Y].](https://www.ebi.ac.uk/pdbe/static/entry/1ira_2_Y_Pfam_PF18452_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>1ira</span> contains 1 copy of Pfam domain <span class='highlight'>PF18452 (Immunoglobulin domain)</span> in <span class='highlight'>Interleukin-1 receptor type 1, soluble form</span>. Showing 1 copy in chain <span class='highlight'>B [auth Y]</span>.")
![The deposited structure of PDB entry 1ira contains 1 copy of Pfam domain PF00340 (Interleukin-1 / 18) in Interleukin-1 receptor antagonist protein. Showing 1 copy in chain A [auth X].](https://www.ebi.ac.uk/pdbe/static/entry/1ira_1_X_Pfam_PF00340_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>1ira</span> contains 1 copy of Pfam domain <span class='highlight'>PF00340 (Interleukin-1 / 18)</span> in <span class='highlight'>Interleukin-1 receptor antagonist protein</span>. Showing 1 copy in chain <span class='highlight'>A [auth X]</span>.")
InterPro annotations
Structure domains
CATH domains
2.60.40.10
Class:
Mainly Beta
Architecture:
Sandwich
Topology:
Immunoglobulin-like
Homology:
Immunoglobulins
Occurring in:
![The deposited structure of PDB entry 1ira contains 3 copies of CATH domain 2.60.40.10 (Immunoglobulin-like) in Interleukin-1 receptor type 1, soluble form. Showing 3 copies in chain B [auth Y].](https://www.ebi.ac.uk/pdbe/static/entry/1ira_2_Y_CATH_2.60.40.10_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>1ira</span> contains 3 copies of CATH domain <span class='highlight'>2.60.40.10 (Immunoglobulin-like)</span> in <span class='highlight'>Interleukin-1 receptor type 1, soluble form</span>. Showing 3 copies in chain <span class='highlight'>B [auth Y]</span>.")
![The deposited structure of PDB entry 1ira contains 1 copy of CATH domain 2.80.10.50 (Trefoil (Acidic Fibroblast Growth Factor, subunit A)) in Interleukin-1 receptor antagonist protein. Showing 1 copy in chain A [auth X].](https://www.ebi.ac.uk/pdbe/static/entry/1ira_1_X_CATH_2.80.10.50_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>1ira</span> contains 1 copy of CATH domain <span class='highlight'>2.80.10.50 (Trefoil (Acidic Fibroblast Growth Factor, subunit A))</span> in <span class='highlight'>Interleukin-1 receptor antagonist protein</span>. Showing 1 copy in chain <span class='highlight'>A [auth X]</span>.")
SCOP annotations![The deposited structure of PDB entry 1ira contains 3 copies of SCOP domain 49159 (I set domains) in Interleukin-1 receptor type 1, soluble form. Showing 3 copies in chain B [auth Y].](https://www.ebi.ac.uk/pdbe/static/entry/1ira_2_Y_SCOP_49159_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>1ira</span> contains 3 copies of SCOP domain <span class='highlight'>49159 (I set domains)</span> in <span class='highlight'>Interleukin-1 receptor type 1, soluble form</span>. Showing 3 copies in chain <span class='highlight'>B [auth Y]</span>.")
![The deposited structure of PDB entry 1ira contains 1 copy of SCOP domain 50362 (Interleukin-1 (IL-1)) in Interleukin-1 receptor antagonist protein. Showing 1 copy in chain A [auth X].](https://www.ebi.ac.uk/pdbe/static/entry/1ira_1_X_SCOP_50362_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>1ira</span> contains 1 copy of SCOP domain <span class='highlight'>50362 (Interleukin-1 (IL-1))</span> in <span class='highlight'>Interleukin-1 receptor antagonist protein</span>. Showing 1 copy in chain <span class='highlight'>A [auth X]</span>.")