1ira

X-ray diffraction
2.7Å resolution

COMPLEX OF THE INTERLEUKIN-1 RECEPTOR WITH THE INTERLEUKIN-1 RECEPTOR ANTAGONIST (IL1RA)

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
Non-polymer only dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Interleukin-1 receptor antagonist protein Chain: X
Molecule details ›
Chain: X
Length: 152 amino acids
Theoretical weight: 17.15 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P18510 (Residues: 26-177; Coverage: 100%)
Gene names: IL1F3, IL1RA, IL1RN
Sequence domains: Interleukin-1 / 18
Structure domains: Trefoil (Acidic Fibroblast Growth Factor, subunit A)
Interleukin-1 receptor type 1, soluble form Chain: Y
Molecule details ›
Chain: Y
Length: 319 amino acids
Theoretical weight: 36.74 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P14778 (Residues: 18-336; Coverage: 58%)
Gene names: IL1R, IL1R1, IL1RA, IL1RT1
Sequence domains:
Structure domains: Immunoglobulins

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: MACSCIENCE M18X
Spacegroup: P212121
Unit cell:
a: 47.2Å b: 84.6Å c: 140.2Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.213 0.213 0.314
Expression systems:
  • Escherichia coli
  • Spodoptera frugiperda