› 1iqw

X-ray diffraction
2.5Å resolution

CRYSTAL STRUCTURE OF THE FAB FRAGMENT OF THE MOUSE ANTI-HUMAN FAS ANTIBODY HFE7A

Released:
DOI: 10.2210/pdb1iqw/pdb
PDB entry 1iqw coloured by chain, front view.
PDB entry 1iqw coloured by chain, side view.
PDB entry 1iqw coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Crystal structure of the antigen-binding fragment of apoptosis-inducing mouse anti-human Fas monoclonal antibody HFE7A.
Ito S, Takayama T, Hanzawa H, Ichikawa K, Ohsumi J, Serizawa N, Hata T, Haruyama H
J Biochem 131 137-43 (2002)
PMID: 11754745

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-213031 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
ANTIBODY M-HFE7A, LIGHT CHAIN Chain: L
Molecule details ›
Chain: L
Length: 218 amino acids
Theoretical weight: 23.92 KDa
Source organism: Mus musculus
Structure domains: Immunoglobulins
ANTIBODY M-HFE7A, HEAVY CHAIN Chain: H
Molecule details ›
Chain: H
Length: 230 amino acids
Theoretical weight: 24.89 KDa
Source organism: Mus musculus
Structure domains: Immunoglobulins

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PHOTON FACTORY BEAMLINE BL-6B
Spacegroup: P212121
Unit cell:
a: 43.435Å b: 73.965Å c: 133.773Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.168 0.168 0.241

Quick links

Citations

4 citation in other articles

Structure of a major antigenic site on the respiratory syncytial virus fusion glycoprotein in complex with neutralizing antibody 101F.
McLellan et al. (2010)
3 more

4 mentions without citation

Crystal structure of snake venom acetylcholinesterase in complex with inhibitory antibody fragment Fab410 bound at the peripheral site: evidence for open and closed states of a back door channel.
Bourne et al. (2015)
3 more