› 1iqa

X-ray diffraction
2.2Å resolution

CRYSTAL STRUCTURE OF THE EXTRACELLULAR DOMAIN OF MOUSE RANK LIGAND

Released:
DOI: 10.2210/pdb1iqa/pdb
PDB entry 1iqa coloured by chain, front view.
PDB entry 1iqa coloured by chain, side view.
PDB entry 1iqa coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Crystal structure of the extracellular domain of mouse RANK ligand at 2.2-A resolution.
Ito S, Wakabayashi K, Ubukata O, Hayashi S, Okada F, Hata T
J Biol Chem 277 6631-6 (2002)
PMID: 11733492

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-128660 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tumor necrosis factor ligand superfamily member 11, soluble form Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 160 amino acids
Theoretical weight: 18 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: O35235 (Residues: 157-316; Coverage: 51%)
Gene names: Opgl, Rankl, Tnfsf11, Trance
Sequence domains: TNF(Tumour Necrosis Factor) family
Structure domains: Jelly Rolls

Ligands and Environments

No bound ligands
1 modified residue:
Ligand MSE 9 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: SPRING-8 BEAMLINE BL40B2
Spacegroup: P212121
Unit cell:
a: 65.68Å b: 78.98Å c: 100.05Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.226 0.226 0.274
Expression system: Escherichia coli

Quick links

Citations

11 review citations

RANK/RANKL: regulators of immune responses and bone physiology.
Leibbrandt et al. (2008)
10 more

3 mentions without citation

Structure-based development of a receptor activator of nuclear factor-kappaB ligand (RANKL) inhibitor peptide and molecular basis for osteopetrosis.
Ta et al. (2010)
2 more