› 1iij

Solution NMR

SOLUTION STRUCTURE OF THE NEU/ERBB-2 MEMBRANE SPANNING SEGMENT

Released:
DOI: 10.2210/pdb1iij/pdb
PDB entry 1iij coloured by chain, ensemble of 5 models, front view.
PDB entry 1iij coloured by chain, ensemble of 5 models, side view.
PDB entry 1iij coloured by chain, ensemble of 5 models, top view.
Source organism: Rattus norvegicus
Primary publication:
Evidence for an alpha-helix --> pi-bulge helicity modulation for the neu/erbB-2 membrane-spanning segment. A 1H NMR and circular dichroism study.
Goetz M, Carlotti C, Bontems F, Dufourc EJ
Biochemistry 40 6534-40 (2001)
PMID: 11371217

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-139066 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Receptor tyrosine-protein kinase erbB-2 Chain: A
Molecule details ›
Chain: A
Length: 35 amino acids
Theoretical weight: 3.89 KDa
Source organism: Rattus norvegicus
Expression system: Not provided
UniProt:
  • Canonical: P06494 (Residues: 647-681; Coverage: 3%)
Gene names: Erbb2, Neu
Sequence domains: Epidermal growth factor receptor transmembrane-juxtamembrane segment

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: molecular dynamics
Expression system: Not provided

Quick links

Citations

6 review citations

Tyrosine kinase receptors as attractive targets of cancer therapy.
Bennasroune et al. (2004)
5 more

4 mentions without citation

Piecing it together: Unraveling the elusive structure-function relationship in single-pass membrane receptors.
Valley et al. (2017)
3 more