X-ray diffraction
2Å resolution

Function and Biology Details

Reaction catalysed:
Preferential cleavage: -Asp-|- >> -Asn-|- > -Met-|-, -Ser-|-.
Biochemical function:
Cellular component:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (3 distinct):
Granzyme B Chain: A
Molecule details ›
Chain: A
Length: 227 amino acids
Theoretical weight: 25.58 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
  • Canonical: P10144 (Residues: 21-247; Coverage: 99%)
Gene names: CGL1, CSPB, CTLA1, GRB, GZMB
Sequence domains: Trypsin
Structure domains: Trypsin-like serine proteases
acetyl-isoleucyl-glutamyl-prolyl-aspartyl-aldehyde peptide INHIBITOR Chain: B
Molecule details ›
Chain: B
Length: 5 amino acids
Theoretical weight: 485 Da
Source organism: Homo sapiens
Expression system: Not provided

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, MAN, BMA, FUC
2 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 17-ID
Spacegroup: P212121
Unit cell:
a: 48.873Å b: 75.081Å c: 80.261Å
α: 90° β: 90° γ: 90°
R R work R free
0.239 0.239 0.296
Expression systems:
  • Spodoptera frugiperda
  • Not provided