1iar

X-ray diffraction
2.3Å resolution

INTERLEUKIN-4 / RECEPTOR ALPHA CHAIN COMPLEX

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Interleukin-4 Chain: A
Molecule details ›
Chain: A
Length: 129 amino acids
Theoretical weight: 14.99 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P05112 (Residues: 25-153; Coverage: 100%)
Gene name: IL4
Sequence domains: Interleukin 4
Structure domains: Growth Hormone; Chain: A;
Soluble interleukin-4 receptor subunit alpha Chain: B
Molecule details ›
Chain: B
Length: 207 amino acids
Theoretical weight: 23.74 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P24394 (Residues: 26-232; Coverage: 26%)
Gene names: 582J2.1, IL4R, IL4RA
Sequence domains: Interleukin-4 receptor alpha chain, N-terminal
Structure domains: Immunoglobulins

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: MPG/DESY, HAMBURG BEAMLINE BW6
Spacegroup: P212121
Unit cell:
a: 49.72Å b: 67.98Å c: 108.46Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.218 0.218 0.289
Expression system: Escherichia coli