1i85

X-ray diffraction
3.2Å resolution

CRYSTAL STRUCTURE OF THE CTLA-4/B7-2 COMPLEX

Released:
Source organism: Homo sapiens

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
T-lymphocyte activation antigen CD86 Chains: A, B
Molecule details ›
Chains: A, B
Length: 110 amino acids
Theoretical weight: 12.85 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P42081 (Residues: 26-134; Coverage: 36%)
Gene names: CD28LG2, CD86
Structure domains: Immunoglobulins
Cytotoxic T-lymphocyte protein 4 Chains: C, D
Molecule details ›
Chains: C, D
Length: 126 amino acids
Theoretical weight: 13.51 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P16410 (Residues: 36-161; Coverage: 67%)
Gene names: CD152, CTLA4
Sequence domains: Immunoglobulin V-set domain
Structure domains: Immunoglobulins

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X9B
Spacegroup: P21
Unit cell:
a: 47.85Å b: 54.56Å c: 103.09Å
α: 90° β: 91.63° γ: 90°
R-values:
R R work R free
0.217 0.217 0.3
Expression system: Escherichia coli BL21(DE3)