› 1i38

X-ray diffraction
2Å resolution

CRYSTAL STRUCTURE OF THE RAT ANDROGEN RECEPTOR LIGAND BINDING DOMAIN T877A MUTANT COMPLEX WITH DIHYDROTESTOSTERONE

Released:
DOI: 10.2210/pdb1i38/pdb
PDB 1i38 coloured by chain and viewed from the front.
PDB 1i38 coloured by chain and viewed from the side.
PDB 1i38 coloured by chain and viewed from the top.
Source organism: Rattus norvegicus
Primary publication:
Crystallographic structures of the ligand-binding domains of the androgen receptor and its T877A mutant complexed with the natural agonist dihydrotestosterone.
Sack JS, Kish KF, Wang C, Attar RM, Kiefer SE, An Y, Wu GY, Scheffler JE, Salvati ME, Krystek SR, Weinmann R, Einspahr HM
Proc. Natl. Acad. Sci. U.S.A. 98 4904-9 (2001)
PMID: 11320241

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Androgen receptor Chain: A
Molecule details ›
Chain: A
Length: 260 amino acids
Theoretical weight: 30.25 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P15207 (Residues: 645-646, 647-902; Coverage: 29%)
Gene names: Ar, Nr3c4
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor

Ligands and Environments

1 bound ligand:
Ligand DHT 1 x DHT
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 17-ID
Spacegroup: P212121
Unit cell:
a: 56.01Å b: 65.71Å c: 70.77Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.28 0.28 0.345
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

64 review citations

An Overview of Next-Generation Androgen Receptor-Targeted Therapeutics in Development for the Treatment of Prostate Cancer.
Mohler et al. (2021)
63 more

11 mentions without citation

Androgen receptor: structure, role in prostate cancer and drug discovery.
Tan et al. (2015)
10 more