PDBe 1i1r

X-ray diffraction
2.4Å resolution

CRYSTAL STRUCTURE OF A CYTOKINE/RECEPTOR COMPLEX

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Interleukin-6 receptor subunit beta Chain: A
Molecule details ›
Chain: A
Length: 303 amino acids
Theoretical weight: 34.66 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P40189 (Residues: 23-325; Coverage: 34%)
Gene name: IL6ST
Sequence domains:
Structure domains: Immunoglobulins
Interleukin-6 homolog Chain: B
Molecule details ›
Chain: B
Length: 181 amino acids
Theoretical weight: 20.86 KDa
Source organism: Human gammaherpesvirus 8
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q98823 (Residues: 24-204; Coverage: 89%)
Gene name: vIL-6
Sequence domains: Interleukin-6/G-CSF/MGF family
Structure domains: Growth Hormone; Chain: A;

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.2
Spacegroup: C2
Unit cell:
a: 103Å b: 123.31Å c: 76.79Å
α: 90° β: 112.03° γ: 90°
R-values:
R R work R free
0.213 0.213 0.256
Expression system: Spodoptera frugiperda