› 1i1a

X-ray diffraction
2.8Å resolution

CRYSTAL STRUCTURE OF THE NEONATAL FC RECEPTOR COMPLEXED WITH A HETERODIMERIC FC

Released:
DOI: 10.2210/pdb1i1a/pdb
PDB entry 1i1a coloured by chain, front view.
PDB entry 1i1a coloured by chain, side view.
PDB entry 1i1a coloured by chain, top view.
Source organism: Rattus norvegicus
Primary publication:
Crystal structure at 2.8 A of an FcRn/heterodimeric Fc complex: mechanism of pH-dependent binding.
Martin WL, West AP, Gan L, Bjorkman PJ
Mol Cell 7 867-77 (2001)
PMID: 11336709

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
PDBe Complex ID:
PDB-CPX-139409 (preferred)
Entry contents:
4 distinct polypeptide molecules
Macromolecules (8 distinct):
IgG receptor FcRn large subunit p51 Chain: A
Molecule details ›
Chain: A
Length: 269 amino acids
Theoretical weight: 30.32 KDa
Source organism: Rattus norvegicus
Expression system: Cricetulus griseus
UniProt:
  • Canonical: P13599 (Residues: 23-291; Coverage: 78%)
Gene names: Fcgrt, Fcrn
Sequence domains:
Structure domains:
Beta-2-microglobulin Chain: B
Molecule details ›
Chain: B
Length: 99 amino acids
Theoretical weight: 11.65 KDa
Source organism: Rattus norvegicus
Expression system: Cricetulus griseus
UniProt:
  • Canonical: P07151 (Residues: 21-119; Coverage: 100%)
Gene name: B2m
Sequence domains: Immunoglobulin C1-set domain
Structure domains: Immunoglobulins
Ig gamma-2A chain C region Chain: C
Molecule details ›
Chain: C
Length: 225 amino acids
Theoretical weight: 25.25 KDa
Source organism: Rattus norvegicus
Expression system: Cricetulus griseus
UniProt:
  • Canonical: P20760 (Residues: 98-322; Coverage: 70%)
Gene name: Igg-2a
Sequence domains: Immunoglobulin C1-set domain
Structure domains: Immunoglobulins
Ig gamma-2A chain C region Chain: D
Molecule details ›
Chain: D
Length: 239 amino acids
Theoretical weight: 26.65 KDa
Source organism: Rattus norvegicus
Expression system: Cricetulus griseus
UniProt:
  • Canonical: P20760 (Residues: 98-322; Coverage: 70%)
Gene name: Igg-2a
Sequence domains: Immunoglobulin C1-set domain
Structure domains: Immunoglobulins

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, FUC
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG, FUC, BMA, MAN, NDG
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG, BMA, MAN, FUL
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG, FUC, BMA, MAN
Carbohydrate polymer
2 bound ligands:
Ligand NAG 2 x NAG
Ligand CYS 2 x CYS
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL9-2
Spacegroup: P212121
Unit cell:
a: 68.358Å b: 74.213Å c: 196.604Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.222 0.222 0.292
Expression system: Cricetulus griseus

Quick links

Citations

64 review citations

Fcgamma receptors as regulators of immune responses.
Nimmerjahn et al. (2008)
63 more

19 mentions without citation

Function and 3D structure of the N-glycans on glycoproteins.
Nagae et al. (2012)
18 more