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HIV INTEGRASE CORE DOMAIN COMPLEXED WITH TETRAPHENYL ARSONIUM

X-ray diffraction
1.7Å resolution
PDB entry 1hyv coloured by chain, front view.
PDB entry 1hyv coloured by chain, side view.
PDB entry 1hyv coloured by chain, top view.
Source organism: Human immunodeficiency virus 1
Assembly composition:
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Capsid protein p24
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Multimeric state: homo dimer
Accessible surface area: 12804.76 Å2
Buried surface area: 4940.78 Å2
Dissociation area: 1,753.26 Å2
Dissociation energy (ΔGdiss): 9.06 kcal/mol
Dissociation entropy (TΔSdiss): 12.34 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-146209

Macromolecules

Integrase
Chain: A
Length: 166 amino acids
Theoretical weight: 18.43 KDa
Source organism: Human immunodeficiency virus 1
Expression system: Escherichia coli
UniProt:
  • Canonical: P12497 (Residues: 1194-1359; Coverage: 12%)
Gene name: gag-pol
Pfam: Integrase core domain
InterPro:
CATH: Ribonuclease H-like superfamily/Ribonuclease H
SCOP: Retroviral integrase, catalytic domain
Integrase in PDB entry 1hyv, assembly 1, front view.
Integrase in PDB entry 1hyv, assembly 1, side view.
Integrase in PDB entry 1hyv, assembly 1, top view.
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