Function and Biology

CRYSTAL STRUCTURE OF L-2-HYDROXYISOCAPROATE DEHYDROGENASE FROM LACTOBACILLUS CONFUSUS AT 2.2 ANGSTROMS RESOLUTION-AN EXAMPLE OF STRONG ASYMMETRY BETWEEN SUBUNITS

Source organism: Weissella confusa
Biochemical function: oxidoreductase activity
Biological process: carboxylic acid metabolic process
Cellular component: not assigned

Sequence families

Pfam Protein families (Pfam)
PF02866
Domain description: lactate/malate dehydrogenase, alpha/beta C-terminal domain
Occurring in:
  1. L-2-hydroxyisocaproate dehydrogenase
1 copy of Pfam domain PF02866 (lactate/malate dehydrogenase, alpha/beta C-terminal domain) in L-2-hydroxyisocaproate dehydrogenase in PDB 1hyh.

PF00056
Domain description: lactate/malate dehydrogenase, NAD binding domain
Occurring in:
  1. L-2-hydroxyisocaproate dehydrogenase
1 copy of Pfam domain PF00056 (lactate/malate dehydrogenase, NAD binding domain) in L-2-hydroxyisocaproate dehydrogenase in PDB 1hyh.

InterPro InterPro annotations
IPR001557
Domain description: L-lactate/malate dehydrogenase
Occurring in:
  1. L-2-hydroxyisocaproate dehydrogenase
IPR015955
Domain description: Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal
Occurring in:
  1. L-2-hydroxyisocaproate dehydrogenase
IPR036291
Domain description: NAD(P)-binding domain superfamily
Occurring in:
  1. L-2-hydroxyisocaproate dehydrogenase
IPR022383
Domain description: Lactate/malate dehydrogenase, C-terminal
Occurring in:
  1. L-2-hydroxyisocaproate dehydrogenase
IPR001236
Domain description: Lactate/malate dehydrogenase, N-terminal
Occurring in:
  1. L-2-hydroxyisocaproate dehydrogenase

Structure domains

CATH CATH domains
3.90.110.10
Class: Alpha Beta
Architecture: Alpha-Beta Complex
Topology: L-2-Hydroxyisocaproate Dehydrogenase; Chain A, domain 2
Homology: Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal
Occurring in:
  1. L-2-hydroxyisocaproate dehydrogenase
1 copy of CATH domain 3.90.110.10 (L-2-Hydroxyisocaproate Dehydrogenase; Chain A, domain 2) in L-2-hydroxyisocaproate dehydrogenase in PDB 1hyh.
3.40.50.720
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: NAD(P)-binding Rossmann-like Domain
Occurring in:
  1. L-2-hydroxyisocaproate dehydrogenase
1 copy of CATH domain 3.40.50.720 (Rossmann fold) in L-2-hydroxyisocaproate dehydrogenase in PDB 1hyh.
SCOP SCOP annotations
56328
Class: Alpha and beta proteins (a+b)
Fold: LDH C-terminal domain-like
Superfamily: LDH C-terminal domain-like
Occurring in:
  1. L-2-hydroxyisocaproate dehydrogenase
1 copy of SCOP domain 56328 (Lactate & malate dehydrogenases, C-terminal domain) in L-2-hydroxyisocaproate dehydrogenase in PDB 1hyh.
51848
Class: Alpha and beta proteins (a/b)
Fold: NAD(P)-binding Rossmann-fold domains
Superfamily: NAD(P)-binding Rossmann-fold domains
Occurring in:
  1. L-2-hydroxyisocaproate dehydrogenase
1 copy of SCOP domain 51848 (LDH N-terminal domain-like) in L-2-hydroxyisocaproate dehydrogenase in PDB 1hyh.