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CRYSTAL STRUCTURE OF L-2-HYDROXYISOCAPROATE DEHYDROGENASE FROM LACTOBACILLUS CONFUSUS AT 2.2 ANGSTROMS RESOLUTION-AN EXAMPLE OF STRONG ASYMMETRY BETWEEN SUBUNITS

X-ray diffraction
2.2Å resolution
PDB 1hyh coloured by chain and viewed from the front.
PDB 1hyh coloured by chain and viewed from the side.
PDB 1hyh coloured by chain and viewed from the top.
Source organism: Weissella confusa
Assembly composition:
homo tetramer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Multimeric state: homo tetramer
Accessible surface area: 37300 Å2
Buried surface area: 19500 Å2
Dissociation area: 2,700 Å2
Dissociation energy (ΔGdiss): 14 kcal/mol
Dissociation entropy (TΔSdiss): 15 kcal/mol
Interface energy (ΔGint): -137 kcal/mol
Symmetry number: 4

Macromolecules

L-2-hydroxyisocaproate dehydrogenase
Chains: A, B, C, D
Length: 309 amino acids
Theoretical weight: 33.08 KDa
Source organism: Weissella confusa
Expression system: Escherichia coli
UniProt:
  • Canonical: P14295 (Residues: 2-310; Coverage: 100%)
Pfam:
InterPro:
CATH:
SCOP:
PDB 1hyh contains 4 copies of L-2-hydroxyisocaproate dehydrogenase in assembly 1. This protein is highlighted and viewed from the front.
PDB 1hyh contains 4 copies of L-2-hydroxyisocaproate dehydrogenase in assembly 1. This protein is highlighted and viewed from the side.
PDB 1hyh contains 4 copies of L-2-hydroxyisocaproate dehydrogenase in assembly 1. This protein is highlighted and viewed from the top.
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